Reigning US Open champion and two-time French Open finalist Dominic Thiem squandered a two-set lead and is out of Roland Garros.

The fourth-seeded Austrian was beaten 4-6, 5-7, 6-3, 6-4, 6-4 by 68th-ranked Pablo Andujar in the first round.

It marked the first time in eight appearances at the clay-court Grand Slam that Thiem lost his opening match.

Andujar also defeated Roger Federer in Geneva earlier this month. It’s the first time in his career that Andujar has come back to win after losing the opening two sets.

Thiem dropped to 11-9 in five-set matches.

Thiem lost the 2018 and 2019 finals to Rafael Nadal.

A former US Open finalist had a hard time on Sunday as well, but Kei Nishikori was able to prevail in his customary five sets.

Nishikori notched a 6-4, 6-7 (4), 6-3, 4-6, 6-4 win over Italian qualifier Alessandro Giannessi in the first round of the French Open.

It was his 10th win in his past 11 five-setters; he’s now 25-7 for his career.

“I have to figure it out, how to win in three sets,” Nishikori said. “It’s really hard to win like this.”

Information from The Associated Press was used in this report.